Ketamine for Migraine

Ketamine, a dissociative anesthetic, has been explored as a potential treatment for various conditions, including migraines.

However, it is important to note that the use of ketamine for migraines is considered off-label, meaning it is not an approved or established standard treatment for this condition.

While there is limited research on the specific use of ketamine for migraines, some studies have shown promising results. Ketamine is thought to work by modulating the activity of certain neurotransmitters in the brain, such as glutamate and N-methyl-D-aspartate (NMDA) receptors, which are believed to be involved in migraine pathophysiology.

One study published in 2014 in the Journal of Headache and Pain investigated the use of intranasal ketamine for the acute treatment of migraines. The researchers found that ketamine provided rapid and sustained relief for some patients, with minimal adverse effects. However, larger and more rigorous studies are needed to further evaluate its safety and efficacy.

It's worth noting that ketamine is a potent anesthetic and can have significant side effects, including hallucinations, confusion, and changes in blood pressure and heart rate.