Promising Arthritis Therapy ( bone marrow , mesenchymal stem cell, cell growth factors)

Bone marrow, which is found inside our bones, contains special cells called mesenchymal stem cells (MSCs). These cells, along with growth factors and cytokines, can help reduce inflammation and promote healing in different parts of our body, like cartilage and bone.

However, MSCs make up only a small fraction (about 0.001%) of the cells in bone marrow. That's why a treatment called bone marrow aspirate concentrate (BMAC) has become popular in recent years for cartilage problems like degeneration, defects, and osteoarthritis.

BMAC has the potential to modify the disease . It's important to mention that more research, specifically well-designed and controlled clinical trials, is needed to fully understand how BMAC works. However, it seems to have a significant positive impact on many patients with osteoarthritis..

BMAC is not only a good source of cells but also contains factors that help with healing. These factors can decrease cell death and inflammation, and promote cell growth, development, and the formation of new blood vessels.

Some of the important factors found in BMAC include platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), insulin-like growth factor I (IGF-I), granulocyte-macrophage colony-stimulating factor (GMCSF), bone morphogenetic protein (BMP-2 and 7), and interleukins (IL-1β, 6, 8) [20, 30, 31].

These factors have positive effects on repairing cartilage and treating conditions like osteoarthritis (OA).